About Us

The Transplant Laboratory

Our transplant laboratory is a fully accredited “state of the art” facility performing histocompatibility testing for deceased and living organ donors and recipients. The laboratory also plays a critical role in the pre and post-transplant evaluation, and successful transplantation of highly sensitized individuals who would be difficult to treat under general conditions. The laboratory has been recognized by National agencies for the accurate and timely testing, and for facilitating the successful transplantation of these difficult to match individuals. We have been recognized for our pioneering advocacy and efforts for living kidney donation and proactive management of living kidney donation programs at both the local and national level. 

The Laboratory is directed by Prakash Rao, PhD, MBA, FACHE, HCLD.  Dr. Rao is a board certified High Complexity Clinical Laboratory Director with certifications in histocompatibility and cancer testing.  Dr. Rao is a Fellow of the American College of Healthcare Executives.  

The Laboratory is maintained by highly trained and motivated personnel certified by several different agencies including ASCP, ABHI, State of New Jersey and New York State.  The laboratory is staffed 24/7 and performs routine as well as STAT testing on potential organ donors and recipients. We are accredited by CAP, CLIA, ASHI, State of New Jersey and New York State.  We have successfully undergone rigorous regulatory body inspections.  

Testing includes HLA typing, HLA antibody screen and identification, crossmatches by complement dependent cytotoxicity and Flow Cytometry, ABO type and screen, Rh and titers.  These procedures form the basis of compatibility determination between potential organ donors and recipients.  In the post-transplant period, the laboratory provides the clinician with tools to monitor and predict impending clinical rejection and graft failure. The laboratory continues to provide these services using state of the art technology and is currently working toward implementing Next Generation Sequencing (NGS) technology for HLA typing.  

The Laboratory provides these services to Newark Beth Israel Medical Center for Heart and Lung transplant, Saint Barnabas Medical Center for Renal/Pancreas transplant, Robert Wood Johnson for Heart and Renal/Pancreas transplant, Hackensack for Renal/Pancreas transplant, University Hospital for Liver transplant, Our Lady of Lourdes for Liver and Renal/Pancreas transplant and Rutgers Cancer Institute of New Jersey for Bone Marrow transplantation.  The laboratory therefore serves as a very valuable resource for transplant center physicians and provides them with the tools to streamline their therapeutic efforts.  The laboratory, in conjunction with our transplant centers has facilitated several ABO and HLA Incompatible transplants and has participated in living kidney donation chains on both local and national levels further giving hope to patients on the transplant registry. In addition to its clinical service duties, the laboratory also serves as a valuable training resource for pathology residents and fellows in training from client transplant institutions, and for local students of the Clinical Laboratory Sciences programs. Cutting edge transplantation research carried out in the laboratory is directed towards identifying markers of donor organ viability and function, personalized transplantation medicine, and regenerative medicine.

We are also very proud of being one of the few Transplant Laboratories with an onsite Digital Pathology program. The ability to carry out biopsy studies of donor kidney tissue in a timely manner has enabled us to ensure significantly improved allocation of donor kidneys, allowing for more successful transplants.

The laboratory continues to play a key role in completing the Circle of Life. To date, the lab is credited with saving the lives of over 10,000 New Jersey residents. 

Testing

  • Immunohematology - hemagglutination method
    ABO/Rh type, A subgrouping
    RBC antibody screening and identification
    ABO antibody titer (isoagglutinin titer)
  • Histocompatibility testing HLA-A B C DR DQ DQA DP typing by rSSOP and SSP
    HLA antibody screening class I and class II by flow cytometry, and identification by Luminex technology
    Crossmatch, T and B cells by CDC and flow cytometry

 

Guidelines

Please refer to the following guidelines for submissions:

Requirements and Instructions for Monthly Specimens

Please use the form below to request canisters:

Request for Canisters

Please use the following forms when submitting tests and/or specimens: 

Request for Pre-Transplant Studies

Request for Pre-Transplant Studies for Paired Exchange Program 

HLA Antibody Test Request Form

Bone Marrow Test Request Form


FOR QUESTIONS OR SUPPLIES CALL
(908) 516-5454

Lab staff

 

Laboratory-at-TSN